ZESTORETIC (Lisinopril) ZESTORETIC® (lisinopril and hydrochlorothiazide) USE IN PREGNANCY When used in pregnancy during the second and third trimesters, ACE inhibitors

The Lipophilicity Examination of Some ACE inhibitors and Hydrochlorothiazide on Cellulose in RP Thin-Layer Chromatography

In this assay, the evaluation of lipophilicity of four ACE-inhibitors and hydrochlorothiazide (HCTZ) with RP-TLC on cellulose layers was described using three binary solvent systems. The selected ACE inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with HCTZ. In addition, the linea...

The Lipophilicity Examination of Some ACE inhibitors and Hydrochlorothiazide on Cellulose in RP Thin-Layer Chromatography

In this assay, the evaluation of lipophilicity of four ACE-inhibitors and hydrochlorothiazide (HCTZ) with RP-TLC on cellulose layers was described using three binary solvent systems. The selected ACE inhibitors had sufficiently different structures which can indicate the method suitability for their lipophilicity evaluation as the model substances in comparison with HCTZ. In addition, the linea...

TARKA® (trandolapril/verapamil hydrochloride ER tablets) USE IN PREGNANCY When used in pregnancy during the second and third trimesters, ACE inhibitors

Preparation of Combination Tablet Containing Lisinopril (10mg)/Hydrochlorothiazide (12.5mg): Characterization and Stability studies

In modern clinical practice, combination fixed - dose tablets have become a baseline foreffective therapy in many clinical conditions. The Hydrochlorothiazide (Hctz) (12.5mg) /Lisinopril (Lis) (10 mg) tablet is a combination drug for treatment of hypertension. In thisstudy, the tablets were prepared by wet granulation method and characterized in terms of weightvariation, hardness, friability, d...

Fetal exposure to lisinopril: neonatal manifestations and management.

The use of angiotensin-converting enzyme (ACE) inhibitors in pregnancy has been associated with neonatal morbidity and mortality. The mechanism of renal dysfunction likely is related to fetal hypotension and prolonged decreased glomerular filtration. Six of 14 previously published cases of neonatal renal failure after maternal ACE inhibitor therapy resulted in death. Eight infants survived afte...